Recognition of quinolone antibiotics by the multidrug efflux transporter MexB of Pseudomonas aeruginosa

The drug/proton antiporter MexB is the engine of the major efflux pump MexAB-OprM in Pseudomonas aeruginosa. This protein is known to transport a large variety of compounds, including antibiotics, thus conferring a multi-drug resistance phenotype. Due to the difficulty of producing co-crystals, only...

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Detalles Bibliográficos
Autores principales: Gervasoni, Silvia, Malloci, Giuliano, Bosin, Andrea, Vargiu, Attilio V., Zgurskaya, Helen I., Ruggerone, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278589/
https://www.ncbi.nlm.nih.gov/pubmed/35766032
http://dx.doi.org/10.1039/d2cp00951j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278589/
https://www.ncbi.nlm.nih.gov/pubmed/35766032
http://dx.doi.org/10.1039/d2cp00951j

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