Cargando…

Re-burying Artificially Exposed Surface of Viral Subunit Vaccines Through Oligomerization Enhances Vaccine Efficacy

Viral subunit vaccines often suffer low efficacy. We recently showed that when taken out of the context of whole virus particles, recombinant subunit vaccines contain artificially exposed surface regions that are non-neutralizing and reduce their efficacy, and thus these regions need to be re-buried...

Descripción completa

Detalles Bibliográficos
Autores principales:	Han, Xuelian, Cai, Zhuming, Dai, Yulong, Huang, He, Cao, Xiangwen, Wang, Yuan, Fang, Yingying, Liu, Gang, Zhang, Min, Zhang, Yuhang, Yang, Binhui, Xue, Wei, Zhao, Guangyu, Tai, Wanbo, Li, Min
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cellular and Infection Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278648/ https://www.ncbi.nlm.nih.gov/pubmed/35846760 http://dx.doi.org/10.3389/fcimb.2022.927674

Ejemplares similares

A Dual Role of Complement Activation in the Development of Fulminant Hepatic Failure Induced by Murine-Beta-Coronavirus Infection
por: Fang, Yingying, et al.
Publicado: (2022)

Identification of amino acid domains of Borrelia burgdorferi P66 that are surface exposed and important for localization, oligomerization, and porin function of the protein
por: Curtis, Michael W., et al.
Publicado: (2022)

Role of the PE/PPE Family in Host–Pathogen Interactions and Prospects for Anti-Tuberculosis Vaccine and Diagnostic Tool Design
por: Qian, Jianing, et al.
Publicado: (2020)

Comparative evaluation of protective immunity against Francisella tularensis induced by subunit or adenovirus-vectored vaccines
por: Zhao, Mengsu, et al.
Publicado: (2023)

Designing Adjuvant Formulations to Promote Immunogenicity and Protective Efficacy of Leptospira Immunoglobulin-Like Protein A Subunit Vaccine
por: Techawiwattanaboon, Teerasit, et al.
Publicado: (2022)

Subunit Vaccine ESAT-6:c-di-AMP Delivered by Intranasal Route Elicits Immune Responses and Protects Against Mycobacterium tuberculosis Infection
por: Ning, Huanhuan, et al.
Publicado: (2021)

Human adenovirus type 7 subunit vaccine induces dendritic cell maturation through the TLR4/NF-κB pathway is highly immunogenic
por: Li, Yaru, et al.
Publicado: (2023)

Vaccination Is Associated With Shorter Time to Target Cycle Threshold Value in Patients With SARS-CoV-2 Omicron Variant
por: Wu, Jiajun, et al.
Publicado: (2022)

Aloe-emodin Attenuates Staphylococcus aureus Pathogenicity by Interfering With the Oligomerization of α-Toxin
por: Jiang, Lanxiang, et al.
Publicado: (2019)

Transcriptome Analysis of Peripheral Blood Mononuclear Cells in SARS-CoV-2 Naïve and Recovered Individuals Vaccinated With Inactivated Vaccine
por: Zhang, Yuwei, et al.
Publicado: (2022)

Prophylactic and Therapeutic HPV Vaccines: Current Scenario and Perspectives
por: Mo, Yicheng, et al.
Publicado: (2022)

Challenges for the development of a universal vaccine against leptospirosis revealed by the evaluation of 22 vaccine candidates
por: Maia, Mara A. C., et al.
Publicado: (2022)

Rational Design of Zika Virus Subunit Vaccine with Enhanced Efficacy
por: Tai, Wanbo, et al.
Publicado: (2019)

Differential Antibody Response to Inactivated COVID-19 Vaccines in Healthy Subjects
por: Zhang, Jiaqi, et al.
Publicado: (2021)

The Quest for a Truly Universal Influenza Vaccine
por: Jang, Yo Han, et al.
Publicado: (2019)

Recent Progress Towards a Gonococcal Vaccine
por: Maurakis, Stavros A., et al.
Publicado: (2022)

Immunological evaluation of recombination PRRSV GP3 and GP5 DNA vaccines in vivo
por: Zhao, Guanyu, et al.
Publicado: (2022)

Protective Role of Rabbit Nucleotide-Binding Oligomerization Domain-2 (NOD2)-Mediated Signaling Pathway in Resistance to Enterohemorrhagic Escherichia coli Infection
por: Guo, Mengjiao, et al.
Publicado: (2018)

Anti-Influenza Effect and Mechanisms of Lentinan in an ICR Mouse Model
por: Cui, Huan, et al.
Publicado: (2022)

Various Adjuvants Effect on Immunogenicity of Puumala Virus Vaccine
por: Kurashova, Svetlana S., et al.
Publicado: (2020)

Pre-Clinical Studies of Inactivated Polyvalent HFRS Vaccine
por: Dzagurova, Tamara K., et al.
Publicado: (2020)

COVID-19 Pandemic and Vaccines Update on Challenges and Resolutions
por: Khan, Wajihul Hasan, et al.
Publicado: (2021)

Preclinical Animal Models for Q Fever Vaccine Development
por: Tesfamariam, Mahelat, et al.
Publicado: (2022)

Identification of Novel Malaria Transmission-Blocking Vaccine Candidates
por: Takashima, Eizo, et al.
Publicado: (2021)

Mucosal Vaccination: A Promising Alternative Against Flaviviruses
por: Luria-Pérez, Rosendo, et al.
Publicado: (2022)

Myeloid-derived suppressor cells and vaccination against pathogens
por: Prochetto, Estefanía, et al.
Publicado: (2022)

Vaccines against candidiasis: Status, challenges and emerging opportunity
por: Sahu, Satya Ranjan, et al.
Publicado: (2022)

Editorial: Pathogenic Neisseria: Pathogenicity, vaccines, and antibiotic resistance
por: Arenas, Jesús
Publicado: (2023)

Editorial: Pathogenesis, vaccines, and antivirals against respiratory viruses
por: Caceres, C. Joaquin, et al.
Publicado: (2023)

Pilus of Streptococcus pneumoniae: structure, function and vaccine potential
por: Miao, Chenglin, et al.
Publicado: (2023)

Humoral immune responses to inactivated COVID-19 vaccine up to 1 year in children with chronic hepatitis B infection
por: Zhou, Yingzhi, et al.
Publicado: (2023)

Therapies and Vaccines Based on Nanoparticles for the Treatment of Systemic Fungal Infections
por: Kischkel, Brenda, et al.
Publicado: (2020)

Editorial: Molecular Vaccines Against Pathogens in the Post-genomic Era
por: Oñate, Angel Alejandro, et al.
Publicado: (2020)

Vaccine Protection of Mice With Primary Immunodeficiencies Against Disseminated Coccidioidomycosis
por: Powell, Daniel A., et al.
Publicado: (2022)

Advances and perspectives in the development of vaccines against highly pathogenic bunyaviruses
por: Chen, Tong, et al.
Publicado: (2023)

Engineering a dual vaccine against COVID-19 and tuberculosis
por: Guthrie, Carlyn Monèt, et al.
Publicado: (2023)

Cellular analysis and metagenomic next-generation sequencing of bronchoalveolar lavage fluid in the distinction between pulmonary non-infectious and infectious disease
por: Pan, Yilin, et al.
Publicado: (2023)

Vaccination with the Crimean-Congo hemorrhagic fever virus viral replicon vaccine induces NP-based T-cell activation and antibodies possessing Fc-mediated effector functions
por: Scholte, F. E. M., et al.
Publicado: (2023)

Incompatible Translation Drives a Convergent Evolution and Viral Attenuation During the Development of Live Attenuated Vaccine
por: Ou, Xumin, et al.
Publicado: (2018)

Protective Immunity Induced by TgMIC5 and TgMIC16 DNA Vaccines Against Toxoplasmosis
por: Zhu, Yu-Chao, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_mqq5pd36vfbj0k2216b0ngiq2o