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Cathepsin K Deficiency Prevented Kidney Damage and Dysfunction in Response to 5/6 Nephrectomy Injury in Mice With or Without Chronic Stress

BACKGROUND: Chronic psychological stress is a risk factor for kidney disease, including kidney dysfunction and hypertension. Lysosomal CatK (cathepsin K) participates in various human pathobiologies. We investigated the role of CatK in kidney remodeling and hypertension in response to 5/6 nephrectom...

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Detalles Bibliográficos
Autores principales: Yue, Xueling, Piao, Limei, Wang, Hailong, Huang, Zhe, Meng, Xiangkun, Sasaki, Takeshi, Inoue, Aiko, Nakamura, Kae, Wan, Ying, Xu, Shengnan, Shi, Guo-Ping, Kim, Weon, Murohara, Toyoaki, Kuzuya, Masafumi, Cheng, Xian Wu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278705/
https://www.ncbi.nlm.nih.gov/pubmed/35726642
http://dx.doi.org/10.1161/HYPERTENSIONAHA.122.19137