Intestinal Gastrin/CCKBR (Cholecystokinin B Receptor) Ameliorates Salt-Sensitive Hypertension by Inhibiting Intestinal Na(+)/H(+) Exchanger 3 Activity Through a PKC (Protein Kinase C)-Mediated NHERF1 and NHERF2 Pathway

BACKGROUND: The present study directly tested the crucial role of intestinal gastrin/CCKBR (cholecystokinin B receptor) in the treatment of salt-sensitive hypertension. METHODS: Adult intestine-specific Cckbr-knockout mice (Cckbr(fl/fl) villin-Cre) and Dahl salt-sensitive rats were studied on the ef...

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Detalles Bibliográficos
Autores principales: Jiang, Xiaoliang, Liu, Yunpeng, Zhang, Xin-Yang, Liu, Xue, Liu, Xing, Wu, Xianxian, Jose, Pedro A., Duan, Shun, Xu, Fu-Jian, Yang, Zhiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278716/
https://www.ncbi.nlm.nih.gov/pubmed/35674015
http://dx.doi.org/10.1161/HYPERTENSIONAHA.121.18791

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278716/
https://www.ncbi.nlm.nih.gov/pubmed/35674015
http://dx.doi.org/10.1161/HYPERTENSIONAHA.121.18791

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