Neuronal activity induces glucosylceramide that is secreted via exosomes for lysosomal degradation in glia

Recessive variants in GBA1 cause Gaucher disease, a prevalent form of lysosome storage disease. GBA1 encodes a lysosomal enzyme that hydrolyzes glucosylceramide (GlcCer) into glucose and ceramide. Its loss causes lysosomal dysfunction and increased levels of GlcCer. We generated a null allele of the...

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Detalles Bibliográficos
Autores principales: Wang, Liping, Lin, Guang, Zuo, Zhongyuan, Li, Yarong, Byeon, Seul Kee, Pandey, Akhilesh, Bellen, Hugo J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278864/
https://www.ncbi.nlm.nih.gov/pubmed/35857503
http://dx.doi.org/10.1126/sciadv.abn3326

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278864/
https://www.ncbi.nlm.nih.gov/pubmed/35857503
http://dx.doi.org/10.1126/sciadv.abn3326

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