Cargando…
Disulfiram/Copper induces antitumor activity against gastric cancer via the ROS/MAPK and NPL4 pathways
Disulfiram (DSF) is an anti-alcoholism medication with superior antitumor activity and clinical safety; its antitumor mechanisms in gastric cancer (GC) have not been fully explored. In the present work, low nontoxic concentrations of copper (Cu) ions substantially enhanced DSF’s antitumor activity,...
Autores principales: | Liu, Yao, Guan, Xin, Wang, Meiling, Wang, Naixue, Chen, Yutong, Li, Baolei, Xu, Zhuxuan, Fu, Fangwei, Du, Cheng, Zheng, Zhendong |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278967/ https://www.ncbi.nlm.nih.gov/pubmed/35290151 http://dx.doi.org/10.1080/21655979.2022.2038434 |
Ejemplares similares
-
Disulfiram and copper combination therapy targets NPL4, cancer stem cells and extends survival in a medulloblastoma model
por: Serra, Riccardo, et al.
Publicado: (2021) -
Disulfiram/Copper Induces Antitumor Activity against Both Nasopharyngeal Cancer Cells and Cancer-Associated Fibroblasts through ROS/MAPK and Ferroptosis Pathways
por: Li, Yiqiu, et al.
Publicado: (2020) -
Seesaw conformations of Npl4 in the human p97 complex and the inhibitory mechanism of a disulfiram derivative
por: Pan, Man, et al.
Publicado: (2021) -
Alcohol-abuse drug disulfiram targets cancer via p97 segregase adapter NPL4
por: Skrott, Zdenek, et al.
Publicado: (2017) -
NPLOC4 is a potential target and a poor prognostic signature in lung squamous cell carcinoma
por: Wang, Naixue, et al.
Publicado: (2023)