In vivo dissection of a clustered-CTCF domain boundary reveals developmental principles of regulatory insulation

Vertebrate genomes organize into topologically associating domains, delimited by boundaries that insulate regulatory elements from nontarget genes. However, how boundary function is established is not well understood. Here, we combine genome-wide analyses and transgenic mouse assays to dissect the r...

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Detalles Bibliográficos
Autores principales: Anania, Chiara, Acemel, Rafael D., Jedamzick, Johanna, Bolondi, Adriano, Cova, Giulia, Brieske, Norbert, Kühn, Ralf, Wittler, Lars, Real, Francisca M., Lupiáñez, Darío G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279147/
https://www.ncbi.nlm.nih.gov/pubmed/35817979
http://dx.doi.org/10.1038/s41588-022-01117-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279147/
https://www.ncbi.nlm.nih.gov/pubmed/35817979
http://dx.doi.org/10.1038/s41588-022-01117-9

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