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Transition between conformational states of the TREK-1 K2P channel promoted by interaction with PIP(2)
Members of the TREK family of two-pore domain potassium channels are highly sensitive to regulation by membrane lipids, including phosphatidylinositol-4,5-bisphosphate (PIP(2)). Previous studies have demonstrated that PIP(2) increases TREK-1 channel activity; however, the mechanistic understanding o...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Biophysical Society
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279171/ https://www.ncbi.nlm.nih.gov/pubmed/35596528 http://dx.doi.org/10.1016/j.bpj.2022.05.019 |