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Redefining GBA gene structure unveils the ability of Cap-independent, IRES-dependent gene regulation

Glucosylceramide is the primary molecule of glycosphingolipids, and its metabolic regulation is crucial for life. Defects in the catabolizing enzyme, glucocerebrosidase (GCase), cause a lysosomal storage disorder known as Gaucher disease. However, the genetic regulation of GCase has not been fully u...

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Detalles Bibliográficos
Autores principales: Miyoshi, Keiko, Hagita, Hiroko, Horiguchi, Taigo, Tanimura, Ayako, Noma, Takafumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279297/
https://www.ncbi.nlm.nih.gov/pubmed/35831491
http://dx.doi.org/10.1038/s42003-022-03577-5