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Redefining GBA gene structure unveils the ability of Cap-independent, IRES-dependent gene regulation
Glucosylceramide is the primary molecule of glycosphingolipids, and its metabolic regulation is crucial for life. Defects in the catabolizing enzyme, glucocerebrosidase (GCase), cause a lysosomal storage disorder known as Gaucher disease. However, the genetic regulation of GCase has not been fully u...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279297/ https://www.ncbi.nlm.nih.gov/pubmed/35831491 http://dx.doi.org/10.1038/s42003-022-03577-5 |