Trp53 controls chondrogenesis and endochondral ossification by negative regulation of TAZ activity and stability via β-TrCP-mediated ubiquitination

Transformation-related protein 53 (Trp53) is a critical regulator of cell fate determination by controlling cell proliferation and differentiation. Ablation of Trp53 signaling in osteoblast lineages significantly promotes osteogenesis, bone formation, and bone remodeling. However, how Trp53 regulate...

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Detalles Bibliográficos
Autores principales: Li, Yang, Yang, Shu-ting, Yang, Shuying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279315/
https://www.ncbi.nlm.nih.gov/pubmed/35831272
http://dx.doi.org/10.1038/s41420-022-01105-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279315/
https://www.ncbi.nlm.nih.gov/pubmed/35831272
http://dx.doi.org/10.1038/s41420-022-01105-2

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