Cargando…
Aurora-A/FOXO3A/SKP2 axis promotes tumor progression in clear cell renal cell carcinoma and dual-targeting Aurora-A/SKP2 shows synthetic lethality
Renal cell carcinoma (RCC) is a common malignant tumor in the world. Histologically, most of RCC is classified as clear cell renal cell carcinoma (ccRCC), which is the most prevalent subtype. The overall survival of patients with ccRCC is poor, thus it is urgent to further explore its mechanism and...
Autores principales: | Li, Pu, Chen, Tingting, Kuang, Peng, Liu, Fujun, Li, Zhongmin, Liu, Fangfang, Wang, Yu, Zhang, Wenfeng, Cai, Xiuyu |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279325/ https://www.ncbi.nlm.nih.gov/pubmed/35831273 http://dx.doi.org/10.1038/s41419-022-04973-9 |
Ejemplares similares
-
Skp-cullin-F box E3 ligase component FBXL2 ubiquitinates Aurora B to inhibit tumorigenesis
por: Chen, B B, et al.
Publicado: (2013) -
USP2 is an SKP2 deubiquitylase that stabilizes both SKP2 and its substrates
por: Zhang, Fengwu, et al.
Publicado: (2021) -
Skp2 and Skp2B team up against Rb and p53
por: Germain, Doris
Publicado: (2011) -
Aurora-A/ERK1/2/mTOR axis promotes tumor progression in triple-negative breast cancer and dual-targeting Aurora-A/mTOR shows synthetic lethality
por: Zhang, Wenfeng, et al.
Publicado: (2019) -
USP10 modulates the SKP2/Bcr-Abl axis via stabilizing SKP2 in chronic myeloid leukemia
por: Liao, Yuning, et al.
Publicado: (2019)