Autism-associated mutation in Hevin/Sparcl1 induces endoplasmic reticulum stress through structural instability

Hevin is a secreted extracellular matrix protein that is encoded by the SPARCL1 gene. Recent studies have shown that Hevin plays an important role in regulating synaptogenesis and synaptic plasticity. Mutations in the SPARCL1 gene increase the risk of autism spectrum disorder (ASD). However, the mol...

Descripción completa

Detalles Bibliográficos
Autores principales: Taketomi, Takumi, Yasuda, Takunori, Morita, Rikuri, Kim, Jaehyun, Shigeta, Yasuteru, Eroglu, Cagla, Harada, Ryuhei, Tsuruta, Fuminori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279342/
https://www.ncbi.nlm.nih.gov/pubmed/35831437
http://dx.doi.org/10.1038/s41598-022-15784-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279342/
https://www.ncbi.nlm.nih.gov/pubmed/35831437
http://dx.doi.org/10.1038/s41598-022-15784-5

Ejemplares similares