The structural basis of BCR-ABL recruitment of GRB2 in chronic myelogenous leukemia

BCR-ABL drives chronic myeloid leukemia (CML). BCR binding to GRB2 transduces signaling via the Ras/MAPK pathway. Despite considerable data confirming the binding, molecular-level understanding of exactly how the two proteins interact, and, especially, what are the determinants of the specificity of...

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Detalles Bibliográficos
Autores principales: Liu, Yonglan, Jang, Hyunbum, Zhang, Mingzhen, Tsai, Chung-Jung, Maloney, Ryan, Nussinov, Ruth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279350/
https://www.ncbi.nlm.nih.gov/pubmed/35651316
http://dx.doi.org/10.1016/j.bpj.2022.05.030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279350/
https://www.ncbi.nlm.nih.gov/pubmed/35651316
http://dx.doi.org/10.1016/j.bpj.2022.05.030

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