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The structural basis of BCR-ABL recruitment of GRB2 in chronic myelogenous leukemia
BCR-ABL drives chronic myeloid leukemia (CML). BCR binding to GRB2 transduces signaling via the Ras/MAPK pathway. Despite considerable data confirming the binding, molecular-level understanding of exactly how the two proteins interact, and, especially, what are the determinants of the specificity of...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Biophysical Society
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279350/ https://www.ncbi.nlm.nih.gov/pubmed/35651316 http://dx.doi.org/10.1016/j.bpj.2022.05.030 |