2.7 Å cryo-EM structure of ex vivo RML prion fibrils

Mammalian prions propagate as distinct strains and are composed of multichain assemblies of misfolded host-encoded prion protein (PrP). Here, we present a near-atomic resolution cryo-EM structure of PrP fibrils present in highly infectious prion rod preparations isolated from the brains of RML prion...

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Detalles Bibliográficos
Autores principales: Manka, Szymon W., Zhang, Wenjuan, Wenborn, Adam, Betts, Jemma, Joiner, Susan, Saibil, Helen R., Collinge, John, Wadsworth, Jonathan D. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279362/
https://www.ncbi.nlm.nih.gov/pubmed/35831275
http://dx.doi.org/10.1038/s41467-022-30457-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279362/
https://www.ncbi.nlm.nih.gov/pubmed/35831275
http://dx.doi.org/10.1038/s41467-022-30457-7

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