Purification of the full-length, membrane-associated form of the antiviral enzyme viperin utilizing nanodiscs

Viperin is a radical S-adenosylmethionine enzyme that catalyzes the formation of the antiviral ribonucleotide, 3’-deoxy-3’,4’-didehydroCTP. The enzyme is conserved across all kingdoms of life, and in higher animals viperin is localized to the ER-membrane and lipid droplets through an N-terminal exte...

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Detalles Bibliográficos
Autores principales: Patel, Ayesha M., Koebke, Karl J., Grunkemeyer, Timothy J., Riordan, Colleen M., Kim, Youngsoo, Bailey, Ryan C., Marsh, E. Neil G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279394/
https://www.ncbi.nlm.nih.gov/pubmed/35831548
http://dx.doi.org/10.1038/s41598-022-16233-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279394/
https://www.ncbi.nlm.nih.gov/pubmed/35831548
http://dx.doi.org/10.1038/s41598-022-16233-z

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