Integrated single cell and spatial transcriptomics reveal autoreactive differentiated B cells in joints of early rheumatoid arthritis

B cells play a significant role in established Rheumatoid Arthritis (RA). However, it is unclear to what extent differentiated B cells are present in joint tissue already at the onset of disease. Here, we studied synovial biopsies (n = 8) captured from untreated patients at time of diagnosis. 3414 i...

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Detalles Bibliográficos
Autores principales: Hardt, Uta, Carlberg, Konstantin, af Klint, Erik, Sahlström, Peter, Larsson, Ludvig, van Vollenhoven, Annika, Hernandez Machado, Susana, Israelsson, Lena, Amara, Khaled, Chemin, Karine, Korotkova, Marina, Karlsson Hedestam, Gunilla B., Catrina, Anca I., Teichmann, Sarah A., Ståhl, Patrik L., Malmström, Vivianne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279471/
https://www.ncbi.nlm.nih.gov/pubmed/35831338
http://dx.doi.org/10.1038/s41598-022-15293-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279471/
https://www.ncbi.nlm.nih.gov/pubmed/35831338
http://dx.doi.org/10.1038/s41598-022-15293-5

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