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Integrated single cell and spatial transcriptomics reveal autoreactive differentiated B cells in joints of early rheumatoid arthritis
B cells play a significant role in established Rheumatoid Arthritis (RA). However, it is unclear to what extent differentiated B cells are present in joint tissue already at the onset of disease. Here, we studied synovial biopsies (n = 8) captured from untreated patients at time of diagnosis. 3414 i...
Autores principales: | Hardt, Uta, Carlberg, Konstantin, af Klint, Erik, Sahlström, Peter, Larsson, Ludvig, van Vollenhoven, Annika, Hernandez Machado, Susana, Israelsson, Lena, Amara, Khaled, Chemin, Karine, Korotkova, Marina, Karlsson Hedestam, Gunilla B., Catrina, Anca I., Teichmann, Sarah A., Ståhl, Patrik L., Malmström, Vivianne |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279471/ https://www.ncbi.nlm.nih.gov/pubmed/35831338 http://dx.doi.org/10.1038/s41598-022-15293-5 |
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