Cargando…

Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope

We studied the prevalent cytotoxic CD8 T cell response mounted against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike glycoprotein(269-277) epitope (sequence YLQPRTFLL) via the most frequent human leukocyte antigen (HLA) class I worldwide, HLA A(∗)02. The Spike P272L mutation tha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dolton, Garry, Rius, Cristina, Hasan, Md Samiul, Wall, Aaron, Szomolay, Barbara, Behiry, Enas, Whalley, Thomas, Southgate, Joel, Fuller, Anna, Morin, Théo, Topley, Katie, Tan, Li Rong, Goulder, Philip J.R., Spiller, Owen B., Rizkallah, Pierre J., Jones, Lucy C., Connor, Thomas R., Sewell, Andrew K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279490/ https://www.ncbi.nlm.nih.gov/pubmed/35931021 http://dx.doi.org/10.1016/j.cell.2022.07.002

Ejemplares similares

GPU-Accelerated Discovery of Pathogen-Derived Molecular Mimics of a T-Cell Insulin Epitope
por: Whalley, Thomas, et al.
Publicado: (2020)

Dual Molecular Mechanisms Govern Escape at Immunodominant HLA A2-Restricted HIV Epitope
por: Cole, David K., et al.
Publicado: (2017)

A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape
por: Kløverpris, Henrik N, et al.
Publicado: (2015)

Peptide Super-Agonist Enhances T-Cell Responses to Melanoma
por: Galloway, Sarah A. E., et al.
Publicado: (2019)

Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope
por: MacLachlan, Bruce J., et al.
Publicado: (2019)

Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig
por: Tungatt, Katie, et al.
Publicado: (2018)

A Molecular Switch Abrogates Glycoprotein 100 (gp100) T-cell Receptor (TCR) Targeting of a Human Melanoma Antigen
por: Bianchi, Valentina, et al.
Publicado: (2016)

CD4(+) T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features
por: Greenshields-Watson, Alexander, et al.
Publicado: (2020)

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity
por: Cole, David K., et al.
Publicado: (2016)

Optimized Peptide–MHC Multimer Protocols for Detection and Isolation of Autoimmune T-Cells
por: Dolton, Garry, et al.
Publicado: (2018)

Cytomegalovirus-Mediated T Cell Receptor Repertoire Perturbation Is Present in Early Life
por: Attaf, Meriem, et al.
Publicado: (2020)

Corrigendum: Cytomegalovirus-Mediated T Cell Receptor Repertoire Perturbation Is Present in Early Life
por: Attaf, Meriem, et al.
Publicado: (2020)

Peptide–MHC Class I Tetramers Can Fail To Detect Relevant Functional T Cell Clonotypes and Underestimate Antigen-Reactive T Cell Populations
por: Rius, Cristina, et al.
Publicado: (2018)

T-cell libraries allow simple parallel generation of multiple peptide-specific human T-cell clones
por: Theaker, Sarah M., et al.
Publicado: (2016)

Genome-wide CRISPR-Cas9 Screening Reveals Ubiquitous T cell Cancer Targeting via the monomorphic MHC class I related protein MR1
por: Crowther, Michael D., et al.
Publicado: (2020)

T cell receptor alpha variable 12‐2 bias in the immunodominant response to Yellow fever virus
por: Bovay, Amandine, et al.
Publicado: (2017)

Molecular Basis of a Dominant T Cell Response to an HIV Reverse Transcriptase 8-mer Epitope Presented by the Protective Allele HLA-B*51:01
por: Motozono, Chihiro, et al.
Publicado: (2014)

Structural Mechanism Underpinning Cross-reactivity of a CD8(+) T-cell Clone That Recognizes a Peptide Derived from Human Telomerase Reverse Transcriptase
por: Cole, David K., et al.
Publicado: (2017)

Preventing tumor escape by targeting a post-proteasomal trimming independent epitope
por: Textor, Ana, et al.
Publicado: (2016)

Do tumor cells escape from natural killer cell cytotoxicity by mimicking dendritic cells?
por: Wurzer, Hannah, et al.
Publicado: (2019)

CD8 Epitope Escape and Reversion in Acute HCV Infection
por: Timm, Joerg, et al.
Publicado: (2004)

Escape of Hepatitis C Virus from Epitope I Neutralization Increases Sensitivity of Other Neutralization Epitopes
por: Gu, Jun, et al.
Publicado: (2018)

Responses of Salmonella biofilms to oxidizing biocides: Evidence of spatial clustering
por: Guest, Kerry, et al.
Publicado: (2022)

Co-Receptor CD8-Mediated Modulation of T-Cell Receptor Functional Sensitivity and Epitope Recognition Degeneracy
por: Szomolay, Barbara, et al.
Publicado: (2013)

Correction: Preventing tumor escape by targeting a post-proteasomal trimming independent epitope
por: Textor, Ana, et al.
Publicado: (2017)

CD8(+) T Cell Cross-Reactivity Profiles and HIV-1 Immune Escape towards an HLA-B35-Restricted Immunodominant Nef Epitope
por: Motozono, Chihiro, et al.
Publicado: (2013)

CTL Escape Mediated by Proteasomal Destruction of an HIV-1 Cryptic Epitope
por: Cardinaud, Sylvain, et al.
Publicado: (2011)

An Elite Controller of Picornavirus Infection Targets an Epitope That Is Resistant to Immune Escape
por: Bell, Michael P., et al.
Publicado: (2014)

Corrigendum: Co-Receptor CD8-Mediated Modulation of T-Cell Receptor Functional Sensitivity and Epitope Recognition Degeneracy
por: Szomolay, Barbara, et al.
Publicado: (2014)

Processing Escape Mechanisms Through Altered Proteasomal Cleavage of Epitopes Affect Immune Response in Pulmonary Neuroendocrine Tumors
por: Wessolly, Michael, et al.
Publicado: (2018)

Integrating genealogical and dynamical modelling to infer escape and reversion rates in HIV epitopes
por: Palmer, Duncan, et al.
Publicado: (2013)

Advances in T-Cell Epitope Engineering
por: Pentier, Johanne M., et al.
Publicado: (2013)

Natural killer group 2D receptor and its ligands in cancer immune escape
por: Duan, Shixin, et al.
Publicado: (2019)

Identification of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors
por: Szomolay, Barbara, et al.
Publicado: (2016)

AIDS virus–specific CD8(+) T lymphocytes against an immunodominant cryptic epitope select for viral escape
por: Maness, Nicholas J., et al.
Publicado: (2007)

Within-Epitope Interactions Can Bias CTL Escape Estimation in Early HIV Infection
por: Garcia, Victor, et al.
Publicado: (2017)

Behçet’s Disease: Do Natural Killer Cells Play a Significant Role?
por: Petrushkin, Harry, et al.
Publicado: (2015)

A Novel Epitope Quality-Based Immune Escape Mechanism Reveals Patient’s Suitability for Immune Checkpoint Inhibition
por: Wessolly, Michael, et al.
Publicado: (2020)

Natural Killer Cells and Neuroblastoma: Tumor Recognition, Escape Mechanisms, and Possible Novel Immunotherapeutic Approaches
por: Bottino, Cristina, et al.
Publicado: (2014)

Acute Myeloid Leukemia Epigenetic Immune Escape From Nature Killer Cells by ICAM-1
por: Xiao, Yang, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_1g3c3a2grv5ugb16vk38vsc970