Integration of tumor extrinsic and intrinsic features associates with immunotherapy response in non-small cell lung cancer

The efficacy of immune checkpoint blockade (ICB) varies greatly among metastatic non-small cell lung cancer (NSCLC) patients. Loss of heterozygosity at the HLA-I locus (HLA-LOH) has been identified as an important immune escape mechanism. However, despite HLA-I disruptions in their tumor, many patie...

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Detalles Bibliográficos
Autores principales: Lau, Denise, Khare, Sonal, Stein, Michelle M., Jain, Prerna, Gao, Yinjie, BenTaieb, Aicha, Rand, Tim A., Salahudeen, Ameen A., Khan, Aly A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279502/
https://www.ncbi.nlm.nih.gov/pubmed/35831288
http://dx.doi.org/10.1038/s41467-022-31769-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279502/
https://www.ncbi.nlm.nih.gov/pubmed/35831288
http://dx.doi.org/10.1038/s41467-022-31769-4

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