The intrinsically disordered protein TgIST from Toxoplasma gondii inhibits STAT1 signaling by blocking cofactor recruitment

Signal transducer and activator of transcription (STAT) proteins communicate from cell-surface receptors to drive transcription of immune response genes. The parasite Toxoplasma gondii blocks STAT1-mediated gene expression by secreting the intrinsically disordered protein TgIST that traffics to the...

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Detalles Bibliográficos
Autores principales: Huang, Zhou, Liu, Hejun, Nix, Jay, Xu, Rui, Knoverek, Catherine R., Bowman, Gregory R., Amarasinghe, Gaya K., Sibley, L. David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279507/
https://www.ncbi.nlm.nih.gov/pubmed/35831295
http://dx.doi.org/10.1038/s41467-022-31720-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279507/
https://www.ncbi.nlm.nih.gov/pubmed/35831295
http://dx.doi.org/10.1038/s41467-022-31720-7

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