PBRM1 deficiency oncogenic addiction is associated with activated AKT–mTOR signalling and aerobic glycolysis in clear cell renal cell carcinoma cells

The PBRM1 (PB1) gene which encodes the specific subunit BAF180 of the PBAF SWI/SNF complex, is highly mutated (~ 40%) in clear cell renal cell carcinoma (ccRCC). However, its functions and impact on cell signalling are still not fully understood. Aerobic glycolysis, also known as the ‘Warburg Effect...

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Detalles Bibliográficos
Autores principales: Tang, Yu, Jin, Yan‐Hong, Li, Hu‐Li, Xin, Hui, Chen, Jin‐Dong, Li, Xue‐Ying, Pan, You‐Fu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279584/
https://www.ncbi.nlm.nih.gov/pubmed/35672925
http://dx.doi.org/10.1111/jcmm.17418

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279584/
https://www.ncbi.nlm.nih.gov/pubmed/35672925
http://dx.doi.org/10.1111/jcmm.17418

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