Inhibition of polycomb repressive complex 2 by targeting EED protects against cisplatin‐induced acute kidney injury

Polycomb repressive complex 2 (PRC2) is a multicomponent complex with methyltransferase activity that catalyzes trimethylation of histone H3 at lysine 27 (H3K27me3). Interaction of the epigenetic reader protein EED with EZH2, a catalytic unit of PRC, allosterically stimulates PRC2 activity. In this...

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Detalles Bibliográficos
Autores principales: Yu, Chao, Li, Tingting, Li, Jialu, Cui, Binbin, Liu, Na, Bayliss, George, Zhuang, Shougang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279598/
https://www.ncbi.nlm.nih.gov/pubmed/35734954
http://dx.doi.org/10.1111/jcmm.17447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279598/
https://www.ncbi.nlm.nih.gov/pubmed/35734954
http://dx.doi.org/10.1111/jcmm.17447

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