Cargando…

Inhibition of polycomb repressive complex 2 by targeting EED protects against cisplatin‐induced acute kidney injury

Polycomb repressive complex 2 (PRC2) is a multicomponent complex with methyltransferase activity that catalyzes trimethylation of histone H3 at lysine 27 (H3K27me3). Interaction of the epigenetic reader protein EED with EZH2, a catalytic unit of PRC, allosterically stimulates PRC2 activity. In this...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yu, Chao, Li, Tingting, Li, Jialu, Cui, Binbin, Liu, Na, Bayliss, George, Zhuang, Shougang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279598/ https://www.ncbi.nlm.nih.gov/pubmed/35734954 http://dx.doi.org/10.1111/jcmm.17447

Ejemplares similares

Polycomb Repressive Complex 2 Modulation through the Development of EZH2–EED Interaction Inhibitors and EED Binders
por: Tomassi, Stefano, et al.
Publicado: (2021)

Depletion of polycomb repressive complex 2 core component EED impairs fetal hematopoiesis
por: Yu, Wenhua, et al.
Publicado: (2017)

The Central Role of EED in the Orchestration of Polycomb Group Complexes
por: Cao, Qi, et al.
Publicado: (2014)

Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED
por: Li, Ling, et al.
Publicado: (2017)

P1498: INHIBITION OF POLYCOMB REPRESSIVE COMPLEX 2 THROUGH EED INDUCES FETAL HEMOGLOBIN IN HEALTHY AND SICKLE CELL DISEASE MODELS
por: Stuart, B., et al.
Publicado: (2022)

The Polycomb group protein Eed protects the inactive X-chromosome from differentiation-induced reactivation
por: Kalantry, Sundeep, et al.
Publicado: (2006)

The Polycomb Group Protein EED Is Dispensable for the Initiation of Random X-Chromosome Inactivation
por: Kalantry, Sundeep, et al.
Publicado: (2006)

Polycomb Protein Eed is Required for Neurogenesis and Cortical Injury Activation in the Subventricular Zone
por: Sun, Bin, et al.
Publicado: (2018)

Human Polycomb group EED protein negatively affects HIV-1 assembly and release
por: Rakotobe, Dina, et al.
Publicado: (2007)

Class IIa histone deacetylase inhibition ameliorates acute kidney injury by suppressing renal tubular cell apoptosis and enhancing autophagy and proliferation
por: Li, Jialu, et al.
Publicado: (2022)

Pharmacological inhibition of SMYD2 protects against cisplatin-induced acute kidney injury in mice
por: Cui, Binbin, et al.
Publicado: (2022)

Histone methyltransferase MLL1 drives renal tubular cell apoptosis by p53-dependent repression of E-cadherin during cisplatin-induced acute kidney injury
por: Zhang, Chunyun, et al.
Publicado: (2022)

Differences between homologous alleles of olfactory receptor genes require the Polycomb Group protein Eed
por: Alexander, Mary Kate, et al.
Publicado: (2007)

Polycomb Protein EED Regulates Neuronal Differentiation through Targeting SOX11 in Hippocampal Dentate Gyrus
por: Liu, Pei-Pei, et al.
Publicado: (2019)

Molecular architecture of polycomb repressive complexes
por: Chittock, Emily C., et al.
Publicado: (2017)

Cholesterol Crystal Embolism and Chronic Kidney Disease
por: Li, Xuezhu, et al.
Publicado: (2017)

Huntingtin facilitates polycomb repressive complex 2
por: Seong, Ihn Sik, et al.
Publicado: (2010)

The structure of Polycomb-repressed chromatin in the bithorax complex
por: Bowman, Sarah K, et al.
Publicado: (2013)

Evolutionary adaptation of the Polycomb repressive complex 2
por: Fischer, Sabrina, et al.
Publicado: (2022)

Maintenance of the functional integrity of mouse hematopoiesis by EED and promotion of leukemogenesis by EED haploinsufficiency
por: Ikeda, Kenichiro, et al.
Publicado: (2016)

Promiscuous RNA binding by Polycomb Repressive Complex 2
por: Davidovich, Chen, et al.
Publicado: (2013)

Molecular architecture of human polycomb repressive complex 2
por: Ciferri, Claudio, et al.
Publicado: (2012)

Polycomb repressive complex 1 controls uterine decidualization
por: Bian, Fenghua, et al.
Publicado: (2016)

The molecular principles of gene regulation by Polycomb repressive complexes
por: Blackledge, Neil P., et al.
Publicado: (2021)

Polycomb Repressive Complex 2 in Eukaryotes—An Evolutionary Perspective
por: Vijayanathan, Mallika, et al.
Publicado: (2022)

The ACF chromatin-remodeling complex is essential for Polycomb repression
por: Wiles, Elizabeth T, et al.
Publicado: (2022)

Critical Roles of Polycomb Repressive Complexes in Transcription and Cancer
por: Dong, Guan-Jun, et al.
Publicado: (2022)

Gene-repressing epigenetic reader EED unexpectedly enhances cyclinD1 gene activation
por: Zhang, Mengxue, et al.
Publicado: (2023)

The Role of Polycomb Repressive Complex in Malignant Peripheral Nerve Sheath Tumor
por: Zhang, Xiyuan, et al.
Publicado: (2020)

Epidermal Growth Factor Receptor: A Potential Therapeutic Target for Diabetic Kidney Disease
por: Sheng, Lili, et al.
Publicado: (2021)

Possible roles for polycomb repressive complex 2 in cereal endosperm
por: Tonosaki, Kaoru, et al.
Publicado: (2015)

LATS2 Positively Regulates Polycomb Repressive Complex 2
por: Torigata, Kosuke, et al.
Publicado: (2016)

Polycomb repressive complex 1 modifies transcription of active genes
por: Pherson, Michelle, et al.
Publicado: (2017)

Polycomb Repressive Complex(es) and Their Role in Adult Stem Cells
por: Flora, Pooja, et al.
Publicado: (2021)

Suramin Alleviates Glomerular Injury and Inflammation in the Remnant Kidney
por: Liu, Na, et al.
Publicado: (2012)

Insulators Target Active Genes to Transcription Factories and Polycomb-Repressed Genes to Polycomb Bodies
por: Li, Hua-Bing, et al.
Publicado: (2013)

Molecular Regulation of the Polycomb Repressive-Deubiquitinase
por: Reddington, Cameron J., et al.
Publicado: (2020)

Exploring the therapeutic potential of targeting polycomb repressive complex 2 in lung cancer
por: Gao, Min, et al.
Publicado: (2023)

Repression of FLOWERING LOCUS C and FLOWERING LOCUS T by the Arabidopsis Polycomb Repressive Complex 2 Components
por: Jiang, Danhua, et al.
Publicado: (2008)

Polycomb Repressive Complex 1 Controls Maintenance of Fungiform Papillae by Repressing Sonic Hedgehog Expression
por: Bar, Carmit, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ena5917ugvarrsn2okvu9pon0k