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Hypoxia induced‐disruption of lncRNA TUG1/PRC2 interaction impairs human trophoblast invasion through epigenetically activating Nodal/ALK7 signalling

Inadequate trophoblastic invasion is considered as one of hallmarks of preeclampsia (PE), which is characterized by newly onset of hypertension (>140/90 mmHg) and proteinuria (>300 mg in a 24‐h urine) after 20 weeks of gestation. Accumulating evidence has indicated that long noncoding RNAs are...

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Detalles Bibliográficos
Autores principales: Hu, Mengsi, Wang, Yao, Meng, Yanping, Hu, Jinxiu, Qiao, Jiao, Zhen, Junhui, Liang, Decai, Fan, Minghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279603/
https://www.ncbi.nlm.nih.gov/pubmed/35729773
http://dx.doi.org/10.1111/jcmm.17450