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Unraveling the drug distribution in brain enabled by MALDI MS imaging with laser-assisted chemical transfer

Accurate localization of central nervous system (CNS) drug distribution in the brain is quite challenging to matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI), owing to the ionization competition/suppression of highly abundant endogenous biomolecules and MALDI matri...

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Detalles Bibliográficos
Autores principales: Guo, Shuai, Li, Kening, Chen, Yanwen, Li, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279630/
https://www.ncbi.nlm.nih.gov/pubmed/35847487
http://dx.doi.org/10.1016/j.apsb.2021.11.007