The Elephant Evolved p53 Isoforms that Escape MDM2-Mediated Repression and Cancer

The p53 tumor suppressor is a transcription factor with roles in cell development, apoptosis, oncogenesis, aging, and homeostasis in response to stresses and infections. p53 is tightly regulated by the MDM2 E3 ubiquitin ligase. The p53–MDM2 pathway has coevolved, with MDM2 remaining largely conserve...

Descripción completa

Detalles Bibliográficos
Autores principales: Padariya, Monikaben, Jooste, Mia-Lyn, Hupp, Ted, Fåhraeus, Robin, Vojtesek, Borek, Vollrath, Fritz, Kalathiya, Umesh, Karakostis, Konstantinos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279639/
https://www.ncbi.nlm.nih.gov/pubmed/35792674
http://dx.doi.org/10.1093/molbev/msac149

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279639/
https://www.ncbi.nlm.nih.gov/pubmed/35792674
http://dx.doi.org/10.1093/molbev/msac149

Ejemplares similares