Blockade of deubiquitinase YOD1 degrades oncogenic PML/RARα and eradicates acute promyelocytic leukemia cells

In most acute promyelocytic leukemia (APL) cells, promyelocytic leukemia (PML) fuses to retinoic acid receptor α (RARα) due to chromosomal translocation, thus generating PML/RARα oncoprotein, which is a relatively stable oncoprotein for degradation in APL. Elucidating the mechanism regulating the st...

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Detalles Bibliográficos
Autores principales: Shao, Xuejing, Chen, Yingqian, Wang, Wei, Du, Wenxin, Zhang, Xingya, Cai, Minyi, Bing, Shaowei, Cao, Ji, Xu, Xiaojun, Yang, Bo, He, Qiaojun, Ying, Meidan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279643/
https://www.ncbi.nlm.nih.gov/pubmed/35847510
http://dx.doi.org/10.1016/j.apsb.2021.10.020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279643/
https://www.ncbi.nlm.nih.gov/pubmed/35847510
http://dx.doi.org/10.1016/j.apsb.2021.10.020

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