Antigenic Determinants of SARS-CoV-2-Specific CD4(+) T Cell Lines Reveals M Protein-Driven Dysregulation of Interferon Signaling

We generated CD4(+) T cell lines (TCLs) reactive to either SARS-CoV-2 spike (S) or membrane (M) proteins from unexposed naïve T cells from six healthy donor volunteers to understand in fine detail whether the S and M structural proteins have intrinsic differences in driving antigen-specific CD4(+) T...

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Detalles Bibliográficos
Autores principales: Gazzinelli-Guimaraes, Pedro H., Sanku, Gayatri, Sette, Alessandro, Weiskopf, Daniela, Schaughency, Paul, Lack, Justin, Nutman, Thomas B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279651/
https://www.ncbi.nlm.nih.gov/pubmed/35844575
http://dx.doi.org/10.3389/fimmu.2022.883159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279651/
https://www.ncbi.nlm.nih.gov/pubmed/35844575
http://dx.doi.org/10.3389/fimmu.2022.883159

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