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Structural Insights Into the High Selectivity of the Anti-Diabetic Drug Mitiglinide
Mitiglinide is a highly selective fast-acting anti-diabetic drug that induces insulin secretion by inhibiting pancreatic K(ATP) channels. However, how mitiglinide binds K(ATP) channels remains unknown. Here, we show the cryo-EM structure of the SUR1 subunit complexed with mitiglinide. The structure...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279661/ https://www.ncbi.nlm.nih.gov/pubmed/35847046 http://dx.doi.org/10.3389/fphar.2022.929684 |