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Structural Insights Into the High Selectivity of the Anti-Diabetic Drug Mitiglinide

Mitiglinide is a highly selective fast-acting anti-diabetic drug that induces insulin secretion by inhibiting pancreatic K(ATP) channels. However, how mitiglinide binds K(ATP) channels remains unknown. Here, we show the cryo-EM structure of the SUR1 subunit complexed with mitiglinide. The structure...

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Detalles Bibliográficos
Autores principales:	Wang, Mengmeng, Wu, Jing-Xiang, Chen, Lei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279661/ https://www.ncbi.nlm.nih.gov/pubmed/35847046 http://dx.doi.org/10.3389/fphar.2022.929684

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