“Pincer movement”: Reversing cisplatin resistance based on simultaneous glutathione depletion and glutathione S-transferases inhibition by redox-responsive degradable organosilica hybrid nanoparticles

The therapeutic efficacy of cisplatin has been restricted by drug resistance of cancers. Intracellular glutathione (GSH) detoxification of cisplatin under the catalysis of glutathione S-transferases (GST) plays important roles in the development of cisplatin resistance. Herein, a strategy of “pincer...

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Detalles Bibliográficos
Autores principales: Niu, Boyi, Zhou, Yixian, Liao, Kaixin, Wen, Ting, Lao, Sixian, Quan, Guilan, Pan, Xin, Wu, Chuanbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279704/
https://www.ncbi.nlm.nih.gov/pubmed/35847508
http://dx.doi.org/10.1016/j.apsb.2021.10.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279704/
https://www.ncbi.nlm.nih.gov/pubmed/35847508
http://dx.doi.org/10.1016/j.apsb.2021.10.013

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