Nuclear TIGAR mediates an epigenetic and metabolic autoregulatory loop via NRF2 in cancer therapeutic resistance

Metabolic and epigenetic reprogramming play important roles in cancer therapeutic resistance. However, their interplays are poorly understood. We report here that elevated TIGAR (TP53-induced glycolysis and apoptosis regulator), an antioxidant and glucose metabolic regulator and a target of oncogeni...

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Detalles Bibliográficos
Autores principales: Wang, Hong, Wang, Qianqian, Cai, Guodi, Duan, Zhijian, Nugent, Zoann, Huang, Jie, Zheng, Jianwei, Borowsky, Alexander D., Li, Jian Jian, Liu, Peiqing, Kung, Hsing-Jien, Murphy, Leigh, Chen, Hong-Wu, Wang, Junjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279715/
https://www.ncbi.nlm.nih.gov/pubmed/35847493
http://dx.doi.org/10.1016/j.apsb.2021.10.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279715/
https://www.ncbi.nlm.nih.gov/pubmed/35847493
http://dx.doi.org/10.1016/j.apsb.2021.10.015

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