Histone H3K27 demethylase KDM6A is an epigenetic gatekeeper of mTORC1 signalling in cancer

OBJECTIVE: Large-scale genome sequencing efforts of human tumours identified epigenetic modifiers as one of the most frequently mutated gene class in human cancer. However, how these mutations drive tumour development and tumour progression are largely unknown. Here, we investigated the function of...

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Detalles Bibliográficos
Autores principales: Revia, Steffie, Seretny, Agnieszka, Wendler, Lena, Banito, Ana, Eckert, Christoph, Breuer, Kersten, Mayakonda, Anand, Lutsik, Pavlo, Evert, Matthias, Ribback, Silvia, Gallage, Suchira, Chikh Bakri, Ismaiel, Breuhahn, Kai, Schirmacher, Peter, Heinrich, Stefan, Gaida, Matthias M, Heikenwälder, Mathias, Calvisi, Diego F, Plass, Christoph, Lowe, Scott W, Tschaharganeh, Darjus F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Pancreas and Liver
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279849/
https://www.ncbi.nlm.nih.gov/pubmed/34509979
http://dx.doi.org/10.1136/gutjnl-2021-325405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279849/
https://www.ncbi.nlm.nih.gov/pubmed/34509979
http://dx.doi.org/10.1136/gutjnl-2021-325405

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