Novel HCN1 Mutations Associated With Epilepsy and Impacts on Neuronal Excitability

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channel plays a critical role in regulating the resting membrane potential and integrating synaptic transmission. Variants of HCN1 have been recognized as causes of epilepsy, and mutant HCN1 channels could act with loss-of-function (LOF), los...

Descripción completa

Detalles Bibliográficos
Autores principales: Xie, Changning, Liu, Fangyun, He, Hailan, He, Fang, Mao, Leilei, Wang, Xiaole, Yin, Fei, Peng, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9280081/
https://www.ncbi.nlm.nih.gov/pubmed/35845605
http://dx.doi.org/10.3389/fnmol.2022.870182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9280081/
https://www.ncbi.nlm.nih.gov/pubmed/35845605
http://dx.doi.org/10.3389/fnmol.2022.870182

Ejemplares similares