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Novel HCN1 Mutations Associated With Epilepsy and Impacts on Neuronal Excitability

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channel plays a critical role in regulating the resting membrane potential and integrating synaptic transmission. Variants of HCN1 have been recognized as causes of epilepsy, and mutant HCN1 channels could act with loss-of-function (LOF), los...

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Detalles Bibliográficos
Autores principales:	Xie, Changning, Liu, Fangyun, He, Hailan, He, Fang, Mao, Leilei, Wang, Xiaole, Yin, Fei, Peng, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9280081/ https://www.ncbi.nlm.nih.gov/pubmed/35845605 http://dx.doi.org/10.3389/fnmol.2022.870182

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