Novel Coumarin–Pyridine Hybrids as Potent Multi-Target Directed Ligands Aiming at Symptoms of Alzheimer’s Disease

In this research, a series of coumarin-based scaffolds linked to pyridine derivatives via a flexible aliphatic linkage were synthesized and assessed as multifunctional anti-AD agents. All the compounds showed acceptable acetylcholinesterase (AChE) inhibition activity in the nanomolar range (IC(50) =...

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Detalles Bibliográficos
Autores principales: Babaei, Elaheh, Küçükkılınç, Tuba Tüylü, Jalili-Baleh, Leili, Nadri, Hamid, Öz, Esin, Forootanfar, Hamid, Hosseinzadeh, Elaheh, Akbari, Tayebeh, Ardestani, Mehdi Shafiee, Firoozpour, Loghman, Foroumadi, Alireza, Sharifzadeh, Mohammad, Mirjalili, Bi Bi Fatemeh, Khoobi, Mehdi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9280334/
https://www.ncbi.nlm.nih.gov/pubmed/35844650
http://dx.doi.org/10.3389/fchem.2022.895483

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9280334/
https://www.ncbi.nlm.nih.gov/pubmed/35844650
http://dx.doi.org/10.3389/fchem.2022.895483

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