Identification of RPL5 gene variants and the risk of hepatic vein thrombosis in Saudi patients

OBJECTIVES: To identify ribosome protein L5 gene variants and the risk of hepatic vein thrombosis in Saudi patients. METHODS: A case-control study was conducted during the period of May 2018 to September 2019. Sixty-five patient cases of hepatic vein thrombosis (HVT) were chosen, and 50 healthy indi...

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Autores principales: Hassan, Fathelrahman M., Alsultan, Afnan A., Alzahrani, Faisal, Albuali, Waleed H., Bubshait, Dalal K., Abass, Elfadil M., Elbasheer, Mudathir A., Alkhanbashi, Abdulmohsen A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Saudi Medical Journal 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9280514/
https://www.ncbi.nlm.nih.gov/pubmed/34470834
http://dx.doi.org/10.15537/smj.2021.42.9.20210240
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author Hassan, Fathelrahman M.
Alsultan, Afnan A.
Alzahrani, Faisal
Albuali, Waleed H.
Bubshait, Dalal K.
Abass, Elfadil M.
Elbasheer, Mudathir A.
Alkhanbashi, Abdulmohsen A.
author_facet Hassan, Fathelrahman M.
Alsultan, Afnan A.
Alzahrani, Faisal
Albuali, Waleed H.
Bubshait, Dalal K.
Abass, Elfadil M.
Elbasheer, Mudathir A.
Alkhanbashi, Abdulmohsen A.
author_sort Hassan, Fathelrahman M.
collection PubMed
description OBJECTIVES: To identify ribosome protein L5 gene variants and the risk of hepatic vein thrombosis in Saudi patients. METHODS: A case-control study was conducted during the period of May 2018 to September 2019. Sixty-five patient cases of hepatic vein thrombosis (HVT) were chosen, and 50 healthy individuals of the same ages and both gender were set as a control group. The genotype of the gene RPL5 was determined by PCR please provide abbreviation in full and capillary electrophoresis. Sanger sequencing for genetically screened variants was applied for the RPL5 gene. RESULTS: Alleles A at variant rs182018447 and T allele at variant rs559377519 were strongly corelated (p=0.009 and p=0.037, respectively) with the risk of HVT. The genotype frequencies of the RPL5 gene, the A/A genotypes at rs182018447 and T/T at rs559377519 were associated with HVT (p=0.000 and p=0.004; respectively) and an increase in risk for HVT among these patients. Please rephrase the highlighted text without using the word respectively. CONCLUSION: Our findings indicate that the 5 genetic novel variants examined in the RPL5 gene were associated with a risk of HVT in all our Saudi cases. Additionally, the A/A at rs182018447 and T/T at rs559377519 genotypes were substantially susceptible to HVT in all these patients.
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spelling pubmed-92805142022-07-19 Identification of RPL5 gene variants and the risk of hepatic vein thrombosis in Saudi patients Hassan, Fathelrahman M. Alsultan, Afnan A. Alzahrani, Faisal Albuali, Waleed H. Bubshait, Dalal K. Abass, Elfadil M. Elbasheer, Mudathir A. Alkhanbashi, Abdulmohsen A. Saudi Med J Original Article OBJECTIVES: To identify ribosome protein L5 gene variants and the risk of hepatic vein thrombosis in Saudi patients. METHODS: A case-control study was conducted during the period of May 2018 to September 2019. Sixty-five patient cases of hepatic vein thrombosis (HVT) were chosen, and 50 healthy individuals of the same ages and both gender were set as a control group. The genotype of the gene RPL5 was determined by PCR please provide abbreviation in full and capillary electrophoresis. Sanger sequencing for genetically screened variants was applied for the RPL5 gene. RESULTS: Alleles A at variant rs182018447 and T allele at variant rs559377519 were strongly corelated (p=0.009 and p=0.037, respectively) with the risk of HVT. The genotype frequencies of the RPL5 gene, the A/A genotypes at rs182018447 and T/T at rs559377519 were associated with HVT (p=0.000 and p=0.004; respectively) and an increase in risk for HVT among these patients. Please rephrase the highlighted text without using the word respectively. CONCLUSION: Our findings indicate that the 5 genetic novel variants examined in the RPL5 gene were associated with a risk of HVT in all our Saudi cases. Additionally, the A/A at rs182018447 and T/T at rs559377519 genotypes were substantially susceptible to HVT in all these patients. Saudi Medical Journal 2021-09 /pmc/articles/PMC9280514/ /pubmed/34470834 http://dx.doi.org/10.15537/smj.2021.42.9.20210240 Text en Copyright: © Saudi Medical Journal https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work.
spellingShingle Original Article
Hassan, Fathelrahman M.
Alsultan, Afnan A.
Alzahrani, Faisal
Albuali, Waleed H.
Bubshait, Dalal K.
Abass, Elfadil M.
Elbasheer, Mudathir A.
Alkhanbashi, Abdulmohsen A.
Identification of RPL5 gene variants and the risk of hepatic vein thrombosis in Saudi patients
title Identification of RPL5 gene variants and the risk of hepatic vein thrombosis in Saudi patients
title_full Identification of RPL5 gene variants and the risk of hepatic vein thrombosis in Saudi patients
title_fullStr Identification of RPL5 gene variants and the risk of hepatic vein thrombosis in Saudi patients
title_full_unstemmed Identification of RPL5 gene variants and the risk of hepatic vein thrombosis in Saudi patients
title_short Identification of RPL5 gene variants and the risk of hepatic vein thrombosis in Saudi patients
title_sort identification of rpl5 gene variants and the risk of hepatic vein thrombosis in saudi patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9280514/
https://www.ncbi.nlm.nih.gov/pubmed/34470834
http://dx.doi.org/10.15537/smj.2021.42.9.20210240
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