3D-QSAR-Based Pharmacophore Modeling, Virtual Screening, and Molecular Dynamics Simulations for the Identification of Spleen Tyrosine Kinase Inhibitors

Spleen tyrosine kinase (SYK) is an essential mediator of immune cell signaling and has been anticipated as a therapeutic target for autoimmune diseases, notably rheumatoid arthritis, allergic rhinitis, asthma, and cancers. Significant attempts have been undertaken in recent years to develop SYK inhi...

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Detalles Bibliográficos
Autores principales: Kumar, Vikas, Parate, Shraddha, Danishuddin, Zeb, Amir, Singh, Pooja, Lee, Gihwan, Jung, Tae Sung, Lee, Keun Woo, Ha, Min Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9280624/
https://www.ncbi.nlm.nih.gov/pubmed/35846777
http://dx.doi.org/10.3389/fcimb.2022.909111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9280624/
https://www.ncbi.nlm.nih.gov/pubmed/35846777
http://dx.doi.org/10.3389/fcimb.2022.909111

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