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Development of an RHEB-Targeting Peptide To Inhibit mTORC1 Kinase Activity
[Image: see text] In cancer, the mechanistic/mammalian target of rapamycin complex-1 (mTORC1) is hyperactivated to promote survival under adverse conditions. The kinase activity of mTORC1 is activated by small-GTPase RHEB-GTP. Therefore, a new modality to inhibit mTORC1 activity has emerged, through...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9280966/ https://www.ncbi.nlm.nih.gov/pubmed/35847293 http://dx.doi.org/10.1021/acsomega.2c01865 |