JOSD2 regulates PKM2 nuclear translocation and reduces acute myeloid leukemia progression

Pyruvate kinase M2 (PKM2) plays an important role in the metabolism and proliferation of leukemia cells. Here, we show that deubiquitinase JOSD2, a novel tumor suppressor, blocks PKM2 nuclear localization by reducing its K433 acetylation in acute myeloid leukemia (AML). Firstly, we show that JOSD2 i...

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Detalles Bibliográficos
Autores principales: Lei, Hu, Yang, Li, Wang, Yingying, Zou, Zhihui, Liu, Meng, Xu, Hanzhang, Wu, Yingli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Correspondence
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281007/
https://www.ncbi.nlm.nih.gov/pubmed/35836282
http://dx.doi.org/10.1186/s40164-022-00295-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281007/
https://www.ncbi.nlm.nih.gov/pubmed/35836282
http://dx.doi.org/10.1186/s40164-022-00295-w

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