Cargando…

Huc-MSCs-derived exosomes attenuate inflammatory pain by regulating microglia pyroptosis and autophagy via the miR-146a-5p/TRAF6 axis

BACKGROUND: Chronic inflammatory pain significantly reduces the quality of life and lacks effective interventions. In recent years, human umbilical cord mesenchymal stem cells (huc-MSCs)-derived exosomes have been used to relieve neuropathic pain and other inflammatory diseases as a promising cell-f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hua, Tong, Yang, Mei, Song, Honghao, Kong, Erliang, Deng, Mengqiu, Li, Yongchang, Li, Jian, Liu, Zhixiao, Fu, Hailong, Wang, Yue, Yuan, Hongbin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281091/ https://www.ncbi.nlm.nih.gov/pubmed/35836229 http://dx.doi.org/10.1186/s12951-022-01522-6

Ejemplares similares

Comparison of effects of HucMSCs, exosomes, and conditioned medium on NASH
por: Liang, Chenchen, et al.
Publicado: (2023)

BRD4 Inhibition Attenuates Inflammatory Pain by Ameliorating NLRP3 Inflammasome-Induced Pyroptosis
por: Hua, Tong, et al.
Publicado: (2022)

The high level of IL-1β in the serum of ACLF patients induces increased IL-8 expression in hUC-MSCs and reduces the efficacy of hUC-MSCs in liver failure
por: Wang, Yong-Hong, et al.
Publicado: (2023)

Efficient expansion and delayed senescence of hUC-MSCs by microcarrier–bioreactor system
por: Wang, Xia, et al.
Publicado: (2023)

Pre-incubation with hucMSC-exosomes prevents cisplatin-induced nephrotoxicity by activating autophagy
por: Wang, Bingying, et al.
Publicado: (2017)

Exosomal miR-365a-5p derived from HUC-MSCs regulates osteogenesis in GIONFH through the Hippo signaling pathway
por: Kuang, Ming-jie, et al.
Publicado: (2020)

Resveratrol Exerts Dosage-Dependent Effects on the Self-Renewal and Neural Differentiation of hUC-MSCs
por: Wang, Xinxin, et al.
Publicado: (2016)

hucMSC-derived exosomes attenuate colitis by regulating macrophage pyroptosis via the miR-378a-5p/NLRP3 axis
por: Cai, Xiu, et al.
Publicado: (2021)

Inhibition of STAT3 signaling as critical molecular event in HUC-MSCs suppressed Glioblastoma Cells
por: Wang, Mingming, et al.
Publicado: (2023)

Corrigendum to: Resveratrol Exerts Dosage-Dependent Effects on the Self-Renewal and Neural Differentiation of hUC-MSCs
por: Wang, Xinxin, et al.
Publicado: (2020)

miR-146a Inhibits dengue-virus-induced autophagy by targeting TRAF6
por: Pu, Jieying, et al.
Publicado: (2017)

Diverse impact of xeno-free conditions on biological and regenerative properties of hUC-MSCs and their extracellular vesicles
por: Bobis-Wozowicz, Sylwia, et al.
Publicado: (2016)

IV/IT hUC-MSCs Infusion in RRMS and NMO: A 10-Year Follow-Up Study
por: Lu, Zhengjuan, et al.
Publicado: (2020)

hucMSCs treatment prevents pulmonary fibrosis by reducing circANKRD42-YAP1-mediated mechanical stiffness
por: Zhang, Haitong, et al.
Publicado: (2023)

Antioxidants Improve the Proliferation and Efficacy of hUC-MSCs against H(2)O(2)-Induced Senescence
por: Zheng, Zhaojuan, et al.
Publicado: (2023)

Novel biphasic mechanism of the canonical Wnt signalling component PYGO2 promotes cardiomyocyte differentiation from hUC-MSCs
por: Shi, Yan, et al.
Publicado: (2023)

Effects of hypoxia-preconditioned HucMSCs on neovascularization and follicle survival in frozen/thawed human ovarian cortex transplanted to immunodeficient mice
por: Cheng, Jiaojiao, et al.
Publicado: (2022)

MG53 protein rejuvenates hUC-MSCs and facilitates their therapeutic effects in AD mice by activating Nrf2 signaling pathway
por: Ma, Shanshan, et al.
Publicado: (2022)

Glycometabolism Reprogramming of Glial Cells in Central Nervous System: Novel Target for Neuropathic Pain
por: Kong, Erliang, et al.
Publicado: (2022)

hUC-MSCs Exert a Neuroprotective Effect via Anti-apoptotic Mechanisms in a Neonatal HIE Rat Model
por: Xu, Jianwei, et al.
Publicado: (2019)

Systematic comparison of hUC-MSCs at various passages reveals the variations of signatures and therapeutic effect on acute graft-versus-host disease
por: Zhao, Qinjun, et al.
Publicado: (2019)

Transplantation of hUC-MSCs seeded collagen scaffolds reduces scar formation and promotes functional recovery in canines with chronic spinal cord injury
por: Li, Xing, et al.
Publicado: (2017)

Lyn‐mediated glycolysis enhancement of microglia contributes to neuropathic pain through facilitating IRF5 nuclear translocation in spinal dorsal horn
por: Kong, Erliang, et al.
Publicado: (2023)

Streptococcus pneumoniae induces pyroptosis through the regulation of autophagy in murine microglia
por: Kim, Ji-Yun, et al.
Publicado: (2015)

Huc-MSC-derived exosomes modified with the targeting peptide of aHSCs for liver fibrosis therapy
por: Lin, Yan, et al.
Publicado: (2022)

hUC-MSCs Attenuate Acute Graft-Versus-Host Disease through Chi3l1 Repression of Th17 Differentiation
por: Liu, Weijiang, et al.
Publicado: (2022)

Microglia secrete miR-146a-5p-containing exosomes to regulate neurogenesis in depression
por: Fan, Cuiqin, et al.
Publicado: (2022)

Human umbilical cord mesenchymal stem cells (hUC-MSCs) alleviate paclitaxel-induced spermatogenesis defects and maintain male fertility
por: Zhang, YuSheng, et al.
Publicado: (2023)

hucMSC-derived exosomes protect ovarian reserve and restore ovarian function in cisplatin treated mice
por: Xiao, Yue, et al.
Publicado: (2023)

A novel minimally invasive OFM technique with orthotopic transplantation of hUC-MSCs and in vivo monitoring of liver metabolic microenvironment in liver fibrosis treatment
por: Yang, Hui, et al.
Publicado: (2021)

A New Self-Healing Hydrogel Containing hucMSC-Derived Exosomes Promotes Bone Regeneration
por: Wang, Li, et al.
Publicado: (2020)

The hUC-MSCs cell line CCRC-1 represents a novel, safe and high-yielding HDCs for the production of human viral vaccines
por: Chen, Ping, et al.
Publicado: (2017)

Phenotype Characteristics and Osteogenic Differentiation Potential of Human Mesenchymal Stem Cells Derived from Amnion Membrane (HAMSCs) and Umbilical Cord (HUC-MSCs)
por: Hendrijantini, Nike, et al.
Publicado: (2019)

hucMSCs Attenuate IBD through Releasing miR148b-5p to Inhibit the Expression of 15-lox-1 in Macrophages
por: Kang, Jingjing, et al.
Publicado: (2019)

Regulation of MiR-146a and TRAF6 in the Diagnose of Lupus Nephritis
por: Zhu, Yunfeng, et al.
Publicado: (2017)

Effects of TRAF3 on the proliferation and migration of lung adenocarcinoma depend partly on pyroptosis
por: Wang, Wangjia, et al.
Publicado: (2023)

TRAF4 acts as a fate checkpoint to regulate the adipogenic differentiation of MSCs by activating PKM2
por: Cen, Shuizhong, et al.
Publicado: (2020)

LncRNA ODIR1 inhibits osteogenic differentiation of hUC-MSCs through the FBXO25/H2BK120ub/H3K4me3/OSX axis
por: He, Shiwei, et al.
Publicado: (2019)

HucMSC‐exosomes carrying miR‐326 inhibit neddylation to relieve inflammatory bowel disease in mice
por: Wang, Gaoying, et al.
Publicado: (2020)

Treatment of Ischemia-Reperfusion Injury of the Skin Flap Using Human Umbilical Cord Mesenchymal Stem Cells (hUC-MSCs) Transfected with “F-5” Gene
por: Leng, Xiangfeng, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_eaebshv19btqo567qluc0fu8f1