Systematic prediction of degrons and E3 ubiquitin ligase binding via deep learning

BACKGROUND: Degrons are short linear motifs, bound by E3 ubiquitin ligase to target protein substrates to be degraded by the ubiquitin-proteasome system. Mutations leading to deregulation of degron functionality disrupt control of protein abundance due to mistargeting of proteins destined for degrad...

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Detalles Bibliográficos
Autores principales: Hou, Chao, Li, Yuxuan, Wang, Mengyao, Wu, Hong, Li, Tingting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281121/
https://www.ncbi.nlm.nih.gov/pubmed/35836176
http://dx.doi.org/10.1186/s12915-022-01364-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281121/
https://www.ncbi.nlm.nih.gov/pubmed/35836176
http://dx.doi.org/10.1186/s12915-022-01364-6

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