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Systematic prediction of degrons and E3 ubiquitin ligase binding via deep learning
BACKGROUND: Degrons are short linear motifs, bound by E3 ubiquitin ligase to target protein substrates to be degraded by the ubiquitin-proteasome system. Mutations leading to deregulation of degron functionality disrupt control of protein abundance due to mistargeting of proteins destined for degrad...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281121/ https://www.ncbi.nlm.nih.gov/pubmed/35836176 http://dx.doi.org/10.1186/s12915-022-01364-6 |