Cargando…

Transient neuroinflammation following surgery contributes to long-lasting cognitive decline in elderly rats via dysfunction of synaptic NMDA receptor

BACKGROUND: Perioperative neurocognitive disorders (PNDs) are considered the most common postoperative complication in geriatric patients. However, its pathogenesis is not fully understood. Surgery-triggered neuroinflammation is a major contributor to the development of PNDs. Neuroinflammation can i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Bo, Qin, Guangcheng, Xiao, Jingyu, Deng, Xiaoyuan, Lin, Aolei, Liu, Hongliang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281167/ https://www.ncbi.nlm.nih.gov/pubmed/35831873 http://dx.doi.org/10.1186/s12974-022-02528-5

Ejemplares similares

Linking NMDA Receptor Synaptic Retention to Synaptic Plasticity and Cognition
por: Franchini, Luca, et al.
Publicado: (2019)

Contribution of NMDA Receptors to Synaptic Function in Rat Hippocampal Interneurons
por: Booker, Sam A., et al.
Publicado: (2021)

Microbiota in neuroinflammation and synaptic dysfunction: a focus on Alzheimer’s disease
por: Bairamian, Diane, et al.
Publicado: (2022)

Forsythoside B ameliorates diabetic cognitive dysfunction by inhibiting hippocampal neuroinflammation and reducing synaptic dysfunction in ovariectomized mice
por: Nan, Xinyu, et al.
Publicado: (2022)

Salvia miltiorrhiza Bunge Blocks Ethanol-Induced Synaptic Dysfunction through Regulation of NMDA Receptor-Dependent Synaptic Transmission
por: Park, Hye Jin, et al.
Publicado: (2016)

Changes in NMDA receptor contribution to synaptic transmission in the brain in a rat model of glaucoma
por: Georgiou, A.L., et al.
Publicado: (2010)

Role of NMDA receptor subtypes in different forms of NMDA-dependent synaptic plasticity
por: Li, Rui, et al.
Publicado: (2007)

F(1)F(0) ATP Synthase–Cyclophilin D Interaction Contributes to Diabetes-Induced Synaptic Dysfunction and Cognitive Decline
por: Yan, Shijun, et al.
Publicado: (2016)

NMDA Receptors Mediate Synaptic Competition in Culture
por: She, Kevin, et al.
Publicado: (2011)

NMDA Receptors Enhance the Fidelity of Synaptic Integration
por: Li, Chenguang, et al.
Publicado: (2021)

Subunit contribution to NMDA receptor hypofunction and redox sensitivity of hippocampal synaptic transmission during aging
por: Kumar, Ashok, et al.
Publicado: (2019)

Beyond NMDA Receptors: Homeostasis at the Glutamate Tripartite Synapse and Its Contributions to Cognitive Dysfunction in Schizophrenia
por: Bauminger, Hagar, et al.
Publicado: (2022)

Dysfunction of inhibitory interneurons contributes to synaptic plasticity via GABABR-pNR2B signaling in a chronic migraine rat model
por: Zeng, Xiaoxu, et al.
Publicado: (2023)

Antioxidant Treatment in Male Mice Prevents Mitochondrial and Synaptic Changes in an NMDA Receptor Dysfunction Model of Schizophrenia
por: Phensy, Aarron, et al.
Publicado: (2017)

NMDA and Dopamine Converge on the NMDA-Receptor to Induce ERK Activation and Synaptic Depression in Mature Hippocampus
por: Kaphzan, Hanoch, et al.
Publicado: (2006)

NMDA Receptors Contribute to Retrograde Synaptic Transmission from Ganglion Cell Photoreceptors to Dopaminergic Amacrine Cells
por: Liu, Lei-Lei, et al.
Publicado: (2017)

Synaptic NMDA receptor activity at resting membrane potentials
por: Chiu, Delia N., et al.
Publicado: (2022)

Altered synaptic glutamate homeostasis contributes to cognitive decline in young APP/PSEN1 mice
por: Wilcox, J.M., et al.
Publicado: (2021)

In vivo effects of antibodies from patients with anti-NMDA receptor encephalitis: further evidence of synaptic glutamatergic dysfunction
por: Manto, Mario, et al.
Publicado: (2010)

Prolonged anesthesia induces neuroinflammation and complement-mediated microglial synaptic elimination involved in neurocognitive dysfunction and anxiety-like behaviors
por: Xu, Feng, et al.
Publicado: (2023)

Cognitive Decline in Neuronal Aging and Alzheimer's Disease: Role of NMDA Receptors and Associated Proteins
por: Avila, Jesús, et al.
Publicado: (2017)

Non-Canonical Roles of Tau and Their Contribution to Synaptic Dysfunction
por: Siano, Giacomo, et al.
Publicado: (2021)

Dysfunction of NMDA receptors in Alzheimer’s disease
por: Zhang, Yan, et al.
Publicado: (2016)

NMDA receptor antibody encephalitis presenting as Transient Epileptic Amnesia
por: Savage, Sharon A., et al.
Publicado: (2019)

T‐type calcium channels contribute to NMDA receptor independent synaptic plasticity in hippocampal regular‐spiking oriens‐alveus interneurons
por: Nicholson, Elizabeth, et al.
Publicado: (2017)

Conserved contributions of NMDA receptor subtypes to synaptic responses in lamina II spinal neurons across early postnatal development
por: Mahmoud, Hadir, et al.
Publicado: (2020)

The influence of gut microbiota alteration on age-related neuroinflammation and cognitive decline
por: Alsegiani, Amsha S., et al.
Publicado: (2022)

Modulation of Synaptic Plasticity by Stress Hormone Associates with Plastic Alteration of Synaptic NMDA Receptor in the Adult Hippocampus
por: Tse, Yiu Chung, et al.
Publicado: (2011)

Properties and molecular identity of NMDA receptors at synaptic and non-synaptic inputs in cerebellar molecular layer interneurons
por: Bidoret, Céline, et al.
Publicado: (2015)

Synaptic GluN2A-Containing NMDA Receptors: From Physiology to Pathological Synaptic Plasticity
por: Franchini, Luca, et al.
Publicado: (2020)

Kalirin-7 is necessary for normal NMDA receptor-dependent synaptic plasticity
por: Lemtiri-Chlieh, Fouad, et al.
Publicado: (2011)

Dynamic Microtubules Promote Synaptic NMDA Receptor-Dependent Spine Enlargement
por: Merriam, Elliott B., et al.
Publicado: (2011)

NMDA receptor-mediated excitotoxicity depends on the coactivation of synaptic and extrasynaptic receptors
por: Zhou, X, et al.
Publicado: (2013)

Efficient Integration of Synaptic Events by NMDA Receptors in Three-Dimensional Neuropil
por: Zheng, Kaiyu, et al.
Publicado: (2015)

Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system
por: Baxter, Paul S., et al.
Publicado: (2015)

Visualization of NMDA receptor-dependent AMPA receptor synaptic plasticity in vivo
por: Zhang, Yong, et al.
Publicado: (2015)

A Novel NMDA Receptor Antagonist Protects against Cognitive Decline Presented by Senescent Mice
por: Companys-Alemany, Júlia, et al.
Publicado: (2020)

Synaptic Dysfunction by Mutations in GRIN2B: Influence of Triheteromeric NMDA Receptors on Gain-of-Function and Loss-of-Function Mutant Classification
por: Elmasri, Marwa, et al.
Publicado: (2022)

Suppressing aberrant GluN3A expression rescues NMDA receptor dysfunction, synapse loss and motor and cognitive decline in Huntington's disease models
por: Marco, Sonia, et al.
Publicado: (2013)

The Impact of Synaptic Zn(2+) Dynamics on Cognition and Its Decline
por: Takeda, Atsushi, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_kesvkshtsrj2eqmhlbomd89tb0