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Inhibitory immune checkpoints cause exhaustion of viral immunity in coronary artery disease
In patients with coronary artery disease, stabilizing post-translational modifications to the mRNA of the immune-checkpoint inhibitor CD155 result in an immunosuppressive macrophage phenotype and impair activation of T cells in response to viral infection.
| Formato: | Online Artículo Texto |
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| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281274/ https://www.ncbi.nlm.nih.gov/pubmed/35856084 http://dx.doi.org/10.1038/s44161-022-00103-y |
| _version_ | 1784746843267137536 |
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| collection | PubMed |
| description | In patients with coronary artery disease, stabilizing post-translational modifications to the mRNA of the immune-checkpoint inhibitor CD155 result in an immunosuppressive macrophage phenotype and impair activation of T cells in response to viral infection. |
| format | Online Article Text |
| id | pubmed-9281274 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-92812742022-07-14 Inhibitory immune checkpoints cause exhaustion of viral immunity in coronary artery disease Nat Cardiovasc Res Research Briefing In patients with coronary artery disease, stabilizing post-translational modifications to the mRNA of the immune-checkpoint inhibitor CD155 result in an immunosuppressive macrophage phenotype and impair activation of T cells in response to viral infection. Nature Publishing Group UK 2022-07-14 2022 /pmc/articles/PMC9281274/ /pubmed/35856084 http://dx.doi.org/10.1038/s44161-022-00103-y Text en © Springer Nature Limited 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
| spellingShingle | Research Briefing Inhibitory immune checkpoints cause exhaustion of viral immunity in coronary artery disease |
| title | Inhibitory immune checkpoints cause exhaustion of viral immunity in coronary artery disease |
| title_full | Inhibitory immune checkpoints cause exhaustion of viral immunity in coronary artery disease |
| title_fullStr | Inhibitory immune checkpoints cause exhaustion of viral immunity in coronary artery disease |
| title_full_unstemmed | Inhibitory immune checkpoints cause exhaustion of viral immunity in coronary artery disease |
| title_short | Inhibitory immune checkpoints cause exhaustion of viral immunity in coronary artery disease |
| title_sort | inhibitory immune checkpoints cause exhaustion of viral immunity in coronary artery disease |
| topic | Research Briefing |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281274/ https://www.ncbi.nlm.nih.gov/pubmed/35856084 http://dx.doi.org/10.1038/s44161-022-00103-y |