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Mechanistic Models of Protein Aggregation Across Length-Scales and Time-Scales: From the Test Tube to Neurodegenerative Disease

Through advances in the past decades, the central role of aberrant protein aggregation has been established in many neurodegenerative diseases. Crucially, however, the molecular mechanisms that underlie aggregate proliferation in the brains of affected individuals are still only poorly understood. U...

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Detalles Bibliográficos
Autores principales: Meisl, Georg, Knowles, Tuomas P. J., Klenerman, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281552/
https://www.ncbi.nlm.nih.gov/pubmed/35844223
http://dx.doi.org/10.3389/fnins.2022.909861