Structural Elements Directing G Proteins and β-Arrestin Interactions with the Human Melatonin Type 2 Receptor Revealed by Natural Variants

[Image: see text] G protein-coupled receptors (GPCRs) can engage distinct subsets of signaling pathways, but the structural determinants of this functional selectivity remain elusive. The naturally occurring genetic variants of GPCRs, selectively affecting different pathways, offer an opportunity to...

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Detalles Bibliográficos
Autores principales: Plouffe, Bianca, Karamitri, Angeliki, Flock, Tilman, Gallion, Jonathan M., Houston, Shane, Daly, Carole A., Bonnefond, Amélie, Guillaume, Jean-Luc, Le Gouill, Christian, Froguel, Phillipe, Lichtarge, Olivier, Deupi, Xavier, Jockers, Ralf, Bouvier, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281605/
https://www.ncbi.nlm.nih.gov/pubmed/35846981
http://dx.doi.org/10.1021/acsptsci.1c00239

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281605/
https://www.ncbi.nlm.nih.gov/pubmed/35846981
http://dx.doi.org/10.1021/acsptsci.1c00239

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