Cargando…

Structural Elements Directing G Proteins and β-Arrestin Interactions with the Human Melatonin Type 2 Receptor Revealed by Natural Variants

[Image: see text] G protein-coupled receptors (GPCRs) can engage distinct subsets of signaling pathways, but the structural determinants of this functional selectivity remain elusive. The naturally occurring genetic variants of GPCRs, selectively affecting different pathways, offer an opportunity to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Plouffe, Bianca, Karamitri, Angeliki, Flock, Tilman, Gallion, Jonathan M., Houston, Shane, Daly, Carole A., Bonnefond, Amélie, Guillaume, Jean-Luc, Le Gouill, Christian, Froguel, Phillipe, Lichtarge, Olivier, Deupi, Xavier, Jockers, Ralf, Bouvier, Michel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281605/ https://www.ncbi.nlm.nih.gov/pubmed/35846981 http://dx.doi.org/10.1021/acsptsci.1c00239

Ejemplares similares

Identification of Key Regions Mediating Human Melatonin Type 1 Receptor Functional Selectivity Revealed by Natural Variants
por: Hegron, Alan, et al.
Publicado: (2021)

Circadian, Sleep and Caloric Intake Phenotyping in Type 2 Diabetes Patients With Rare Melatonin Receptor 2 Mutations and Controls: A Pilot Study
por: Imam, Akram, et al.
Publicado: (2020)

Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT(2) receptor reciprocally modulate their signaling functions
por: Oishi, Atsuro, et al.
Publicado: (2017)

β-arrestin-dependent and -independent endosomal G protein activation by the vasopressin type 2 receptor
por: Daly, Carole, et al.
Publicado: (2023)

β-Arrestin-dependent and -independent endosomal G protein activation by the vasopressin type 2 receptor
por: Daly, Carole, et al.
Publicado: (2023)

Editorial: Melatonin in Health and Disease
por: Olcese, James, et al.
Publicado: (2020)

Next-generation sequencing for identifying new genes in rare genetic diseases: many challenges and a pinch of luck
por: Bonnefond, Amélie, et al.
Publicado: (2013)

Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation
por: Mayer, Daniel, et al.
Publicado: (2019)

Extracellular acidification stimulates GPR68 mediated IL-8 production in human pancreatic β cells
por: Chandra, Vikash, et al.
Publicado: (2016)

Predicting phenotype from genotype: Improving accuracy through more robust experimental and computational modeling
por: Gallion, Jonathan, et al.
Publicado: (2017)

Evolutionary action and structural basis of the allosteric switch controlling β(2)AR functional selectivity
por: Schönegge, Anne-Marie, et al.
Publicado: (2017)

Heterodimerization and Subcellular Distribution of Melatonin and Cannabinoid Type 1 Receptors
por: Cui, Yuanxu, et al.
Publicado: (2021)

Melatonin Target Proteins: Too Many or Not Enough?
por: Liu, Lei, et al.
Publicado: (2019)

Negative regulation of melatonin secretion by melatonin receptors in ovine pinealocytes
por: Lépinay, Julie, et al.
Publicado: (2021)

Monitoring G protein-coupled receptor and β-arrestin trafficking in live cells using enhanced bystander BRET
por: Namkung, Yoon, et al.
Publicado: (2016)

The constitutive activity of the viral-encoded G protein-coupled receptor US28 supports a complex signalling network contributing to cancer development
por: Daly, Carole A., et al.
Publicado: (2020)

Arrestin-1 engineering facilitates complex stabilization with native rhodopsin
por: Haider, Raphael S., et al.
Publicado: (2019)

Pistacia vera Extract Potentiates the Effect of Melatonin on Human Melatonin MT(1) and MT(2) Receptors with Functional Selectivity
por: Labani, Nedjma, et al.
Publicado: (2023)

Melatonin: Facts, Extrapolations and Clinical Trials
por: Boutin, J. A., et al.
Publicado: (2023)

Design and Validation of the First Family of Photo-Activatable Ligands for Melatonin Receptors
por: Somalo-Barranco, Gloria, et al.
Publicado: (2022)

β-arrestin1 and 2 exhibit distinct phosphorylation-dependent conformations when coupling to the same GPCR in living cells
por: Haider, Raphael S., et al.
Publicado: (2022)

SAT025 Characterization Of The Melatonin Type 1 Receptor / Cannabinoid Type 1 Receptor (MT1/CB1) Heteromers
por: Cui, Yuanxu, et al.
Publicado: (2023)

Author Correction: Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response
por: Benredjem, Besma, et al.
Publicado: (2020)

Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response
por: Benredjem, Besma, et al.
Publicado: (2019)

Melatonin promotes regeneration of injured motor axons via MT(1) receptors
por: Stazi, Marco, et al.
Publicado: (2020)

Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs
por: Avet, Charlotte, et al.
Publicado: (2022)

NACHO: an R package for quality control of NanoString nCounter data
por: Canouil, Mickaël, et al.
Publicado: (2019)

Convergent evolution of tertiary structure in rhodopsin visual proteins from vertebrates and box jellyfish
por: Gerrard, Elliot, et al.
Publicado: (2018)

Genetic and biased agonist-mediated reductions in β-arrestin recruitment prolong cAMP signaling at glucagon family receptors
por: Jones, Ben, et al.
Publicado: (2020)

Recurrent high-impact mutations at cognate structural positions in class A G protein-coupled receptors expressed in tumors
por: Huh, Eunna, et al.
Publicado: (2021)

On the origins of arrestin and rhodopsin
por: Alvarez, Carlos E
Publicado: (2008)

Defining the roles of arrestin2 and arrestin3 in vasoconstrictor receptor desensitization in hypertension
por: Willets, Jonathon M., et al.
Publicado: (2015)

β-Arrestin2 is increased in liver fibrosis in humans and rodents
por: Schierwagen, Robert, et al.
Publicado: (2020)

Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation
por: Brouwers, Bas, et al.
Publicado: (2021)

Not all arrestins are created equal: Therapeutic implications of the functional diversity of the β-arrestins in the heart
por: Lymperopoulos, Anastasios, et al.
Publicado: (2019)

LSD-stimulated behaviors in mice require β-arrestin 2 but not β-arrestin 1
por: Rodriguiz, Ramona M., et al.
Publicado: (2021)

Glutamate transporters: The arrestin connection
por: Zafra, Francisco, et al.
Publicado: (2016)

The single nucleotide β -arrestin2 variant, A248T, resembles dynamical properties of activated arrestin
por: ŞENSOY, Özge
Publicado: (2020)

Challenges for Cellular Endocrinology: Improving the Detection Methods and Closing the Gap between in Vitro and in Vivo Observations
por: Jockers, Ralf
Publicado: (2010)

Frontiers Commentary on Tallet et al. Investigation of Prolactin Receptor Activation and Blockade Using Time-Resolved Fluorescence Resonance Energy Transfer
por: Jockers, Ralf
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_10ldl0u4sm54i9gj4mb9t60fbc